The cancer death rate is increasing every year, mostly due to invasion and metastasis. Accordingly, overcoming cancer invasion and metastasis
should be the top priority in today’s cancer research. To this end, we need solid basic studies on molecular and cellular mechanisms of invasion and
metastasis, and simultaneous efforts on developing novel therapeutic measures.
We have been studying mechanisms of colon cancer development and progression using various mouse models. Our recent focuses include interaction between cancer cells and microenvironment, metastasis, and personalized medicine using the patient-derived xenograft (PDX) and the patient-derived spheroid models.