Selected publications

Morimoto, T., Takemura, Y., Miura, T., Yamamoto, T., Kakizaki, F., An, H., Maekawa, H., Yamaura, T., Kawada, K., Sakai, Y., Yuba, Y., Terajima, H., Obama, K., Taketo, M. M., Miyoshi, H.
Novel and efficient method for culturing patient-derived gastric cancer stem cells.
Cancer Sci., DOI: 10.1111/cas.15840
Matsubara, H., Miyoshi, H., Kakizaki, F., Morimoto, T., Kawada, K., Yamamoto, T., Obama, K., Sakai, Y., Taketo, M. M.
Efficacious combination drug treatment for colorectal cancer that overcomes resistance to KRAS G12C inhibitors.
Mol. Cancer Ther., 22: 529-538, 2023.
Kitano, S., Yamamoto, T., Taketo, M. M.
Novel parameter for cancer chemosensitivity to fibroblast growth factor receptor inhibitors.
Cancer Sci., 113: 4005-4010, 2022.
Yamamoto, T., Miyoshi, H., Kakizaki, F., Maekawa, H., Yamaura, T., Morimoto, T., Katayama, T., Kawada. K., Sakai, Y., Taketo, M. M.
Chemosensitivity of patient-derived cancer stem cells identifies colorectal cancer patients with potential benefit from FGFR inhibitor therapy.
Cancers (Basel). 2020 Jul 22;12(8):E2010.
*Yamaura, T., *Miyoshi, H., Maekawa, H., Morimoto, T., Yamamoto, T., Kakizaki, F., Higasa, K., Kawada. K., Matsuda, F., Sakai, Y., Taketo, M. M.
Accurate diagnosis of mismatch repair deficiency in colorectal cancer using high-quality DNA samples from cultured stem cells.
Oncotarget 9: 37534-37548, 2018. *Co-first author
*Maekawa, H., *Miyoshi, H., Yamaura, T., Itatani, T., Kawada, K., Sakai, Y., Taketo, M. M.
A chemosensitivity study of colorectal cancer using xenografts of patient-derived tumor-initiating cells.
Mol. Cancer Ther. 17: 2187-2196, 2018. *Co-first author
Aoyama, N., Miyoshi, H., Miyachi, H., Sonoshita, M., Okabe, M., Taketo, M. M.
Transgenic mice that accept luciferase- or GFP-expressing syngeneic tumor cells at high efficiencies.
Genes to Cells 23: 580-589, 2018.
Miyoshi, H., Maekawa, H., Kakizaki, F., Yamaura, T., Kawada, K., Sakai, Y., Taketo, M. M.
An improved method for culturing patient-derived colorectal cancer spheroids.
Oncotarget 9: 21950-21964, 2018.
Okada, Y., Sonoshita, M., Kakizaki, F., Aoyama, N., Itatani, Y., Uegaki, M., Sakamoto, H., Kobayashi, T., Inoue, T., Kamba, T., Suzuki, A., Ogawa, O., Taketo, M. M.
Amino-terminal enhancer of split gene AES encodes a tumor and metastasis suppressor of prostate cancer.
Cancer Sci. 2017 Feb 8.
Kakizaki, F., Sonoshita, M., Miyoshi, H., Itatani, Y., Ito, S., Kawada, K., Sakai, Y., Taketo, M. M.
Expression of metastasis suppressor gene AES driven by a YY element in a CpG island promoter and transcription factor YY2.
Cancer Sci., 107, 1622-1631, 2016
Itatani, Y., Sonoshita, M., Kakizaki, F., Okawa, K., Stifani, S., Itoh, H., Sakai, Y., Taketo, M.M.
Characterization of Aes nuclear foci in colorectal cancer cells.
J. Biochem. 159:133-140, 2016
Sonoshita, M., Itatani, Y., Kakizaki, F., Sakimura, K., Terashima, T., Katsuyama, Y., Sakai, Y., Taketo, M. M.
Promotion of colorectal cancer invasion and metastasis through activation of NOTCH-DAB1-ABL-RHOGEF protein TRIO.
Cancer Discov. 5: 198-211, 2015
Hirai, H., Fujishita, T., Kurimoto, K., Miyachi, H., Kitano, S., Inamoto, S., Itatani, Y., Saitou, M., Maekawa, T., Taketo, M. M.
CCR1-mediated accumulation of myeloid cells in the liver microenvironment promoting mouse colon cancer metastasis.
Clin. Exp. Metastasis 31: 977-989, 2014.
Itatani, Y., Kawada, K., Fujishita, T., Kakizaki, F., Hirai, H., Matsumoto, T., Iwamoto, M., Inamoto, S., Hatano, E., Hasegawa, S., Maekawa, T., Uemoto, S., Sakai, Y., Taketo, M. M.
Loss of SMAD4 from colorectal cancer cells promotes CCL15 expression to recruit CCR1+ myeloid cells and facilitate liver metastasis.
Gastroenterology. 145: 1064-1075, 2013.
Taketo M. M.
Roles of stromal microenvironment in colon cancer progression.
J. Biochem. 151: 477-481, 2012.
Fujishita, T, Aoki, M, Taketo, M. M.
JNK Signaling Promotes Intestinal Tumorigenesis Through Activation of mTOR Complex 1 in Apc(Δ716) Mice.
Gastroenterology 140: 1556-1563, 2011.
Sonoshita, M., Aoki, M., Fuwa, H., Aoki K., Hosogi, H., Sakai, Y., Hashida, H., Takabayashi, A., Sasaki, M., Robine, S., Itoh, K., Yoshioka, K., Kakizaki, F., Kitamura, T., Oshima, M., Taketo, M. M.
Suppression of Colon Cancer Metastasis by Aes through Inhibition of Notch Signaling.
Cancer Cell. 19: 125-137, 2011.
Kawada, K., Taketo, M. M.
Significance and Mechanism of Lymph Node Metastasis in Cancer Progression.
Cancer Res. 71: 1214-1218, 2011.
Kakizaki, F., Aoki, K., Miyoshi, H., Carrasco, N., Aoki, M., Taketo, M. M.
CDX Transcription Factors Positively Regulate Expression of Solute carrier family 5, member 8 (SLC5A8).
Gastroenterology, 138: 627-635, 2010.
Arimura, S., Matsunaga, A., Kitamura, T., Aoki, K., Aoki, M. and Taketo, M. M.
Reduced level of Smoothened suppresses intestinal tumorigenesis by down-regulation of Wnt signaling.
Gastroenterology 137:629-638, 2009.
Taketo, M. M. and Edelmann, W.
Mouse models of colon cancer.
Gastroenterology 136:780-798, 2009.
Fujishita, T., Aoki, K., Lane, H.A., Aoki, M., and Taketo, M. M.
Inhibition of mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcΔ716 mice.
Proc. Natl. Acad. Sci. U.S.A. 105:13544-13549, 2008.
Kitamura, T. and Taketo, M. M.
Keeping out the bad guys: gateway to cellular target therapy.
Cancer Res. 67:10099-10102, 2007.
Kojima, Y., Miyoshi, H., Clevers, H. C., Oshima, M., Aoki, M., and Taketo, M. M.
Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity regulating kinases signaling.
J. Biol. Chem. 282: 23532-23540, 2007.
Kitamura, T., Kometani, K., Hashida, H., Matsunaga, A., Miyoshi, H., Hosogi, H., Aoki, M., Oshima, M., Hattori, M., Takabayashi, A., Minato, M. and Taketo, M. M.
SMAD4-deficient intestinal tumors recruit CCR1+-myeloid cells that help invasion.
Nat. Genet. 39: 467-475, 2007.
Kawada, K., Hosogi, H., Sonoshita, M., Sakashita, H., Manabe, T., Shimahara, Y., Sakai, Y., Takabayashi, A, Oshima, M. and Taketo, M. M.
Chemokine receptor CXCR3 promotes colon cancer metastasis to lymph nodes.
Oncogene 26: 4679-4688, 2007.
Oshima, H., Matsunaga, A., Taketo, M. M., and Oshima, M.
Carcinogenesis in mouse stomach by simultaneous activation of the Wnt signaling and prostaglandin E2 pathway.
Gastroenterology 131: 1086-1095, 2006.
Oshima, M., Oshima, H., Matsunaga, A. and Taketo, M. M.
Hyperplastic gastric tumors with spasmolytic polypeptide-expressing metaplasia caused by tumor necrosis factor-alpha-dependent inflammation in cyclooxygenase-2/microsomal prostaglandin E synthase-1 transgenic mice.
Cancer Res. 65: 9147-9151, 2005.
Li, Q., Ishikawa, T., Oshima, M. and Taketo, M. M.
The threshold level of adenomatous polyposis coli protein for mouse intestinal tumorigenesis.
Cancer Res. 65: 8622-8627, 2005.
Li, Q., Ishikawa, T., Miyoshi, H., Oshima, M. and Taketo, M. M.
A targeted mutation of Nkd1 impairs mouse spermatogenesis.
J. Biol. Chem. 280: 2831-2839, 2005.
Fujishita, T., Doi, Y., Sonoshita, M., Hiai, H., Oshima, M., Huebner, K., Croce, C. M. and Taketo, M. M.
Development of spontaneous tumours and intestinal lesions in Fhit gene knockout mice.
Br. J. cancer 91: 1571-1574, 2004.
Kawada, K., Sonoshita, M, Sakashita, H., Takabayashi, A, Yamaoka, Y., Manabe, T., Inaba, K., Minato, N., Oshima, M. and Taketo, M. M.
Pivotal Role of CXCR3 in melanoma cell metastasis to lymph nodes.
Cancer Res. 64: 4010-4017, 2004.
Oshima, H., Oshima, M., Inaba, K. and Taketo, M. M.
Hyperplastic gastric tumors induced by activated macrophages in COX-2/mPGES-1 transgenic mice.
EMBO J. 23: 1669-1678, 2004.
Aoki, K., Tamai, Y., Horiike, S., Oshima, M. and Taketo, M. M.
Colonic polyposis caused by mTOR-mediated chromosomal instability in ApcΔ716Cdx2 compound mutant mice.
Nat. Genet. 35: 323-330, 2003.
Takeda, H., Sonoshita, M., Oshima, H., Sugihara, K., Chulada, P. C., Langenbach, R., Oshima, M. and Taketo, M. M.
Cooperation of cyclooxygenase 1 and cyclooxygenase 2 in intestinal polyposis.
Cancer Res. 63: 4872-4877, 2003.
Ishikawa T. Tamai, Y., Li, Q., Oshima, M. and Taketo, M. M.
Requirement for tumor suppressor Apc in the morphogenesis of anterior and ventral mouse embryo.
Dev. Biol. 253: 230-246, 2003.
Taketo, M. M. and Sonoshita, M.
Phospholipase A2 and apoptosis.
Biochim. Biophys. Acta. 1585: 72-76, 2002.
Sonoshita, M., Takaku, K., Oshima, M., Sugihara, K. and Taketo, M. M.
Cyclooxygenase-2 expression in fibroblasts and endothelial cells of intestinal polyps.
Cancer Res. 62: 6846-6849, 2002.
Oshima, M. and Taketo, M. M.
COX selectivity and animal models for colon cancer.
Curr. Pharm. Des. 8: 1021-1034, 2002.
Seno, H., Oshima, M., Ishikawa, T., Oshima, H., Takaku, K., Chiba, T., Narumiya, S. and Taketo, M. M.
Cyclooxygenase 2- and prostaglandin E2 receptor EP2-dependent angiogenesis in ApcΔ716 mouse intestinal polyps.
Cancer Res: 62: 506-511, 2002.
Sonoshita, M., Takaku, K., Sasaki, N., Sugimoto, Y., Ushikubi, F., Narumiya, S., Oshima, M., and Taketo, M. M.
Acceleration of intestinal polyposis through prostaglandin receptor EP2 in ApcΔ716 knockout mice.
Nature Med. 7, 1048-1051, 2001.
Oshima, M., Murai, N., Kargman, S., Arguello, M., Luk, P., Kwong, E., Takedo, M. M. and Evans, J. F.
Chemoprevention of intestinal polyposis in the ApcΔ716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor.
Cancer Res. 61: 1733-1740, 2001.
Ishikawa, T., Tamai, Y., Zorn, A. M., Yoshida, H., Seldin, M. F., Nishikawa, S. and Taketo, M. M.
Mouse Wnt receptor gene Fzd5 essential for yolk sac and placental angiogenesis.
Development 128: 25-33, 2001.
Takaku, K., Sonoshita, M., Sasaki, N., Uozumi, N., Doi, Y., Shimizu, T. and Taketo, M. M.
Suppression of intestinal polyposis in ApcΔ716 knockout mice by an additional mutation in the cytosolic phospholipase A2 gene.
J. Biol. Chem. 275: 34013-34016, 2000.
Takaku, K., Miyoshi, H., Matsunaga, A., Oshima, M., Sasaki, N. and Taketo, M. M.
Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice.
Cancer Res. 59: 6113-6117, 1999.
Tamai, Y., Nakajima, R., Ishikawa, T., Takaku, K., Seldin, M. F. and Taketo, M. M.
Colonic hamartoma development by anomalous duplication in Cdx2 knockout mice.
Cancer Res. 59: 2965-2970, 1999.
Harada, N., Tamai, Y., Ishikawa, T., Sauer, B., Takaku, K., Oshima, M. and Taketo, M. M.
Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene.
EMBO J. 18: 5931-5942, 1999.
Taketo, M.M.
Cyclooxygenase-2 inhibitors in tumorigenesis.
J. Natl. Cancer Inst. 90: 1529-1536 (Part I) and 1609-1620 (Part II), 1998.
Fujita, T., Matsui, M., Takaku, K., Uetake, H., Ichikawa, W., Taketo, M.M., Sugihara, K.
Size- and invasion-dependent increase in cyclooxygenase 2 levels in human colorectal carcinomas.
Cancer Res. 58: 4823-4826, 1998.
Takaku, K., Oshima, M., Miyoshi, H., Matsui, M., Seldin, M. F. and Taketo, M.M.
Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes.
Cell 92: 645-656, 1998.
Oshima, H., Oshima, M., Kobayashi, M., Tsutsumi, M. and Taketo, M. M.
Morphological and molecular processes of polyp formation in Apc (delta716) knockout mice.
Cancer Res 57: 1644-1649, 1997.
Oshima, M., Dinchuk, J. E., Kargman, S. L., Oshima, H., Hancock, B., Kwong, E., Trzaskos, J. M., Evans, J. F. and Taketo, M. M.
Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2).
Cell 87: 803-809, 1996.
Oshima, M., Oshima, H. and Taketo, M. M.
TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis.
Dev. Biol. 179: 297-302, 1996.
Oshima, M., Oshima, H., Kitagawa, K., Kobayashi, M., Itakura, C. and Taketo, M. M.
Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene.
Proc. Natl. Acad. Sci. U.S.A. 92: 4482-4486, 1995.
Taketo, M., Schroeder, A. C., Mobraaten, L. E., Gunning, K. B., Hanten, G., Fox, R. R., Roderick, T. H., Stewart, C. L., Lilly, F., Hansen, C. T. and Overbeek, P. A.
FVB/N: an inbred mouse strain preferable for transgenic analyses.
Proc. Natl. Acad. Sci. U.S.A. 88: 2065-2069, 1991.

 

Selected publications (Hiroyuki Miyoshi)

*Yamaura, T., *Miyoshi, H., Maekawa, H., Morimoto, T., Yamamoto, T., Kakizaki, F., Higasa, K., Kawada. K., Matsuda, F., Sakai, Y., Taketo, M. M.
Accurate diagnosis of mismatch repair deficiency in colorectal cancer using high-quality DNA samples from cultured stem cells.
Oncotarget 9: 37534-37548, 2018. *Co-first author
*Maekawa, H., *Miyoshi, H., Yamaura, T., Itatani, T., Kawada, K., Sakai, Y., Taketo, M. M.
A chemosensitivity study of colorectal cancer using xenografts of patient-derived tumor-initiating cells.
Mol. Cancer Ther. 17: 2187-2196, 2018. *Co-first author
Aoyama, N., Miyoshi, H., Miyachi, H., Sonoshita, M., Okabe, M., Taketo, M. M.
Transgenic mice that accept luciferase- or GFP-expressing syngeneic tumor cells at high efficiencies.
Genes to Cells 23: 580-589, 2018.
Miyoshi, H., Maekawa, H., Kakizaki, F., Yamaura, T., Kawada, K., Sakai, Y., Taketo, M. M.
An improved method for culturing patient-derived colorectal cancer spheroids.
Oncotarget 9: 21950-21964, 2018.
Miyoshi, H.
Wnt-expressing cells in the intestines: guides for tissue remodeling.
J. Biochem. (Review), 161, 19-25, 2017.
*Miyoshi, H., *VanDussen, K. L., Malvin, N. P., Ryu, S. H., Wang, Y., Sonnek, N. M., Lai, C-W., Stappenbeck, T. S.
  * Co-first author
Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium.
EMBO J., 36, 5-24, 2017.
Sun, L., Miyoshi, H., Origanti, S., Nice, T. J., Barger, A. C., Manieri, N. A., Fogel, L. A., French, A. R., Piwnica-Worms, D., Piwnica-Worms, H., Virgin, H. W., Lenschow, D. J., Stappenbeck, T. S.
Type I Interferons link viral infection to enhanced epithelial turnover and repair.
Cell Host & Microbe, 17: 85-97, 2015.
VanDussen, K. L., Marinshaw, J. M., Shaikh, N., Miyoshi, H., Moon, C., Tarr, P. I., Ciorba, M. A., Stappenbeck, T. S.
Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays.
Gut, 64: 911-920, 2015.
Moon, C., VanDussen, K. L., Miyoshi, H., Stappenbeck, T. S.
Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosis.
Mucosal Immunol., 7: 818-828, 2014.
Miyoshi, H., Stappenbeck, T. S.
In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture.
Nat. Protocols, 8: 2471-2482, 2013.
Patel, K. K., Miyoshi, H., Beatty, W. L., Head, R. D., Malvin, N. P., Cadwell, K., Seglen, P. O., Dinauer, M. C., Virgin, H. W., Stappenbeck, T. S.
Autophagy proteins control goblet cell function by potentiating reactive oxygen species production.
EMBO J., 32: 3130-3144, 2013.
Miyoshi, H., Ajima, R., Luo, C., Yamaguchi, T. P., Stappenbeck, T. S.
Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury.
Science, 338: 108-113, 2012.
Miyoshi, H., Deguchi, A., Nakau, M., Kojima, Y., Mori, A., Oshima, M., Aoki, M., Taketo, M. M.
Hepatocellular carcinoma development induced by conditional β-catenin activation in Lkb1+/- mice.
Cancer Sci., 100: 2046-2053, 2009.
Stappenbeck, T. S., Miyoshi, H.
The role of stromal stem cells in tissue regeneration and wound repair.
Science (Review), 324: 1666-1669, 2009.
Seno, H., Miyoshi, H., Brown, S. L., Geske, M. J., Colonna, M., Stappenbeck, T. S.
Efficient colonic mucosal wound repair requires Trem2 signaling.
Proc. Natl. Acad. Sci. U S A., 106: 256-261, 2009.
Cadwell, K., Liu, J. Y., Brown, S. L., Miyoshi, H., Loh, J., Lennerz, J. K., Kishi, C., Kc, W., Carrero, J. A., Hunt, S., Stone, C. D., Brunt, E. M., Xavier, R. J., Sleckman, B. P., Li, E., Mizushima, N., Stappenbeck, T. S., Virgin, H. W.
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells.
Nature, 456: 259-263, 2008.
Miyoshi, H., Nakau, M, Ishikawa, T., Seldin, M. F., Oshima, M., Taketo, M. M.
Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice.
Cancer Res., 62: 2261-2266, 2002.

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